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Buy Prednisone

Buy generic Prednisone online without prescription

This drug is used in many countries and can be purchased under the following brands:

Prednisone, Apo-prednisone, Cordrol, Cortancyl, Decortin, Decortisyl, Deltra, Diadreson, Hostacortin, Marsone, Meticorten, Nisone, Norapred, Nosipren, Orasone, Panasol-s: 40 mg, 20 mg, 10 mg.

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Pharmacological Effects Prednisone - glucocorticoid, an anti-inflammatory, anti-allergic.

Stabilizes cell membranes, including lysosomal reduces the yield of the lysosomal proteolytic enzymes (deceleration phase and alterations limitation inflammatory focus), inhibits phospholipase A2. The drug Prednisone violates libration of arachidonic acid, as a consequence, inhibits PG synthesis, hydroxy acids, and leukotrienes. Prednisone inhibits the activity of hyaluronidase and reduces the permeability of capillaries (depression phase of exudation), fibroblast activity (inhibition of proliferation phase). Prednisone antiallergic properties due to violation of mast cell degranulation, leukotriene synthesis and decrease antibody production suppression, antishock - sodium and water retention, increased vascular response to exogenous and endogenous vasoconstrictors. It has a stimulating effect on cardiac activity, antitoxic - accelerated inactivation of toxic substances in the liver, decrease the permeability of cell membranes.

When administered is easily absorbed, Cmax observed after 1-2 hours in the blood plasma. Bioavailability greater than 90%. Prednisone biotransformation, mainly in the liver, in the kidneys. With an increase in the dose increases T1 / 2, total body clearance, volume of distribution and protein binding.

Influences carbohydrate, protein, fat and water-salt metabolism. Increases in blood glucose levels, contributes to the accumulation of glycogen in the liver, increasing gluconeogenesis. Activates catabolism slows regeneration control deamination of amino acids in the liver, adipose tissue promotes redistribution, delays in the body of sodium and water, increases the excretion of potassium.

Prednisone stimulates the cardiovascular system, increases the tone of the arterioles and myocardial contractility, increased cardiac output and stroke, stimulates the central nervous system, has a detoxifying effect and immunosuppressive, causing increased secretion of gastric mucosa and gastric acidity.

Application of the substance Prednisone.

Prednisone prescribed for such diseases:

  • agranulocytosis
  • congenital adrenal hyperplasia
  • allergic diseases
  • alopecia
  • Addison's disease
  • bronchial asthma
  • hemolytic anemia
  • hepatitis
  • hypoglycemic state
  • dermatomyositis
  • itch
  • Infectious mononucleosis
  • adrenocortical
  • lupus erythematosus
  • megakaryoblastoma
  • lipoid nephrosis
  • acute failure
  • acute pancreatitis
  • hepatic coma
  • prevention and treatment of shock
  • psoriasis
  • pemphigus
  • various forms of leukemia
  • rheumatism
  • rheumatoid arthritis
  • seborrheic dermatitis
  • scleroderma
  • thrombocytopenic purpura
  • periarteritis nodosa
  • eczema
  • exfoliative dermatitis
  • erythroderma

Contraindications:

Hypersensitivity, gastric ulcer and duodenal ulcer in the acute phase of osteoporosis, a tendency to thromboembolism, renal failure, severe arterial hypertension, systemic fungal infections, viral infections, vaccination period, the active form of tuberculosis, productive symptoms in psychiatric diseases.

Restrictions apply to: Diabetes mellitus, non-specific infection, latent tuberculosis, pregnancy.

Side effects of the drug:

resistance to reduce the infections, hyperglycemia, until the development of steroid diabetes, negative nitrogen balance, osteoporosis, aseptic bone necrosis, increased gastric acidity, ulcerogenic effect on gastrointestinal tract, hypokalemia, sodium and water retention, edema, hypertension, increased blood clotting, increased weight body, steroid cataract, latent glaucoma, menstrual disorders in women, insomnia, muscle weakness. You may experience withdrawal symptoms associated with inhibition of the function or atrophy of the adrenal cortex.

Interaction:

It accelerates the elimination of barbiturates, digitoxin, penicillin, chloramphenicol. Phenobarbital, phenytoin, diphenhydramine, ephedrine increase the rate of biotransformation. The danger increases hypokalemia in combination with amphotericin B and cardiac glycosides. In combination with acetylsalicylic acid may develop gipoprotrombinemii.

Dosage and administration:

For adults, the initial dose of 20-30 mg daily, maintenance dose of 5-10 mg per day.
If necessary, the initial dose may be 15-100 mg per day, supporting 5-15 mg per day. The daily dose should be reduced gradually. For children, the initial dose is 1.2 mg per 1 kg of body weight per day, in 4-6 receptions supporting Prednisone dose - 300-600 mg / kg per day. The highest single dose for adults - 15 mg daily - 100 mg. In emergency conditions the patient using large doses of the drug for a short time.
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